Sigourney Weaver and David Hyde Pierce are teaming up to play siblings this Fall as both make a return to the stage in a Chekhov-inspired play.

Weaver, a three-time Oscar nominee, and Tony Award-winning Pierce will star in Christopher Durang’s new work, “Vanya and Sonia and Masha and Spike.”

The play, which takes characters and themes from Chekhov and sets them in present day Pennsylvania, will start life at the McCarter Theatre in New Jersey before jumping to New York’s Lincoln Center Theater in October.